Metachromatic leukodystrophy - Genetics Home Reference - NIH - adult metachromatic leukodystrophy

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Metachromatic Leukodystrophy - NORD (National Organization for Rare Disorders) adult metachromatic leukodystrophy


49 rows · Sep 19, 2014 · Metachromatic leukodystrophy is an inherited condition characterized by the accumulation of fats called sulfatides in cells, especially cells of the nervous system.This accumulation results in progressive destruction of white matter of the brain, which consists of nerve fibers covered by myelin.. Affected individuals experience progressive deterioration of intellectual functions and motor.

Metachromatic leukodystrophy (MLD) is a rare hereditary disease characterized by accumulation of fats called sulfatides. This causes the destruction of the protective fatty layer (myelin sheath) surrounding the nerves in both the central nervous system and the peripheral nervous system.

Jun 13, 2003 · Introduction. Metachromatic leukodystrophy is one of the most serious genetic demyelination disorders. 1 It is an autosomal recessive lysosomal disease characterized by demyelination of the white matter in the central nervous system and the peripheral nerves. The relevant gene is located on chromosome 22q13.Cited by: 15.

Metachromatic leukodystrophy is an inherited disorder characterized by the accumulation of fats called sulfatides in cells. This accumulation especially affects cells in the nervous system that produce myelin, the substance that insulates and protects nerves.Nerve cells covered by .